The store will not work correctly when cookies are disabled.
Images
L-NAME product vial image | Hello Bio
L-NAME product vial image | Hello Bio
Biological Data
| Biological description | Non-selective nitric oxide synthase (NOS) inhibitor. Also inhibits cyclic GMP (IC50 = 3.1 μM). Methyl ester pro-drug of L-NNA. Induces hypertension. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in water (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | Nomega-Nitro-L-arginine methyl ester hydrochloride |
| Chemical structure | ![L-NAME [51298-62-5] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "L-NAME [51298-62-5]") |
| Molecular Formula | C7H15N5O4.HCl |
| PubChem identifier | 135193 |
| SMILES | COC(=O)[C@H](CCCN=C(N)N[N+](=O)[O-])N.Cl |
| InChi | InChI=1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1 |
| InChiKey | QBNXAGZYLSRPJK-JEDNCBNOSA-N |
References for L-NAME
References are publications that support the biological activity of the product
-
L-NAME in the cardiovascular system - nitric oxide synthase activator?
Kopincová J et al (2012) Pharmacol Rep 64(3) : 511-20. -
Nitric oxide synthases: structure, function and inhibition.
Alderton WK et al (2001) Biochem J 357(Pt 3) : 593-615. -
Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo.
Rees DD et al (1990) Br J Pharmacol 101(3) : 746-52.
Publications
These publications cite the use of L-NAME purchased from Hello Bio:
-
Vascular remodelling in a mouse model of heart failure with preserved ejection fraction.
Sanhueza-Olivares F et al (2025) The Journal of physiology -
Cerebellar interneurons control fear memory consolidation via learning-induced HCN plasticity.
Carzoli KL et al (2023) Cell reports 42 : 113057
Non-selective NOS inhibitor. Induces hypertension.
![L-NAME [51298-62-5] Chemical Structure](https://media-m2stage.hellobio.com/media/catalog/product//h/b/hb1352.png "L-NAME [51298-62-5]")
Understanding purity and quality - a guide for life scientists
