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Biological Data
| Biological description | Highly potent bisphosphonate, shows variety of biological actions. Ras signaling inhibitor. Inhibits bone metastasis. Shows apoptotic effects and inhibits proliferation. Also reduces tumour burden and growth. |
Solubility & Handling
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | Zoledronate |
| Chemical structure | ![Zoledronic acid [118072-93-8] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Zoledronic acid [118072-93-8]") |
| Molecular Formula | C5H10N2O7P2 |
| SMILES | C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O |
| InChiKey | XRASPMIURGNCCH-UHFFFAOYSA-N |
References for Zoledronic acid
References are publications that support the biological activity of the product
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Zoledronic acid affects the cytotoxic effects of Chlamydia pneumoniae and the modulation of cytokine production in human osteosarcoma cells.
Rizzo A et al (2014) Int Immunopharmacol 22(1) : 66-72. -
Zoledronic acid inhibits macrophage/microglia-assisted breast cancer cell invasion.
Rietkötter E et al (2013) Oncotarget 4(9) : 1449-60. -
Antineoplastic activity of zoledronic acid and denosumab.
Zwolak P et al (2013) Anticancer Res 33(8) : 2981-8.
Highly potent bisphosphonate, shows variety of biological actions
![Zoledronic acid [118072-93-8] Chemical Structure](https://media-m2stage.hellobio.com/media/catalog/product//h/b/hb0674.png "Zoledronic acid [118072-93-8]")
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