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Biological Data
| Biological description | Calmodulin (CaM) antagonist. Reverses the inhibitory effect of insulin via dibutytyl cAMP. A chlorine-deficient inactive analogue of W-7. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in DMSO (50mM) or water (10mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | N-(6-Aminohexyl)-1-naphthalenesulfonamide hydrochloride |
| Chemical structure | ![W-5 hydrochloride [61714-25-8] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "W-5 hydrochloride [61714-25-8]") |
| Molecular Formula | C16H22N2O2S.HCl |
| PubChem identifier | 173829 |
| SMILES | Cl.NCCCCCCNS(=O)(=O)C1=C2C=CC=CC2=CC=C1 |
| InChiKey | HOCSVIGHWPLMFC-UHFFFAOYSA-N |
References for W-5 hydrochloride
References are publications that support the biological activity of the product
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W-5 and quin 2-AM reverse the inhibitory effect of insulin on lipolysis due to dibutyryl cAMP.
Goko H et al (1999) Diabetes Res Clin Pract 44(2) : 101-6. -
Effect of calmodulin antagonists on auxin-induced elongation.
Raghothama KG et al (1985) Plant Physiol 79(1) : 28-33. -
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation.
Hidaka H et al (1981) Proc Natl Acad Sci U S A 78(7) : 4354-7.
Calmodulin (CaM) antagonist
![W-5 hydrochloride [61714-25-8] Chemical Structure](https://media-m2stage.hellobio.com/media/catalog/product//h/b/hb0649.png "W-5 hydrochloride [61714-25-8]")
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