Why TCB-32 and TCB-621 are a Superior Replacement to FGF2
★ Introduction ★ Comparison Table ★ Benefits ★ Applications ★ Try ThioFlavin X ★
Discover TCB-32 and TCB-621: The Next Generation FGF2 Small Molecule Alternative
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Key features
Graphs
FGF2 vs TCB-32 and TCB-621: A Comparative Overview
| Feature | FGF2 | FGF2 (heat stable) | TCB-32 | TCB-541 | TCB-621 |
|---|---|---|---|---|---|
| Type | |||||
| Stability (37) | |||||
| Working Concentration | |||||
| Consistency | High batch to batch variability in activity and endotoxin. | Defined chemical consistency (>98% purity) | |||
| Max effect | |||||
| Equivalent cost | |||||
| Media change frequency | |||||
| Handling and Storage | |||||
| Potency | |||||
| Total Bioavailability (AUC) | |||||
| Signaling Mechanism | |||||
| Risk of contamination | |||||
Try TCB-32 Try TCB-541 Try TCB-621
Why Scientists Are Switching to TCB-32 and TCB-621
- Enhanced Fluorescence Brightness: Clearer images and early aggregate detection[1].
- Higher Binding Affinity: More efficient labeling of Aβ structures[1,3].
- Better Spectral Discrimination: Enables improved contrast and ratiometric detection[2].
- Super-Resolution Imaging: Compatible with STED and dSTORM[2].
- Consistency for Quantitative Assays: Ideal for reproducible fluorescence-based studies[1,3].
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Applications of TCB-32, TCB-541 and TCB-621
- Alzheimer’s and Parkinson’s Research: Detect Aβ and tau aggregates with fidelity[2,3].
- Protein Misfolding Mechanisms: Visualize early-stage β-sheet structures[1,3].
- Super-Resolution Microscopy: Reveal fine structure of amyloids with precision[2].
- Fluorescence-Based Quantitation: Track aggregation in vitro or in cells[1].
Make the Switch to TCB Today
Whether you are performing high-resolution microscopy, studying neurodegenerative pathways, or screening aggregation modulators, ThX is the next-gen solution that outperforms Thioflavin T.
| Equivalent Packsize | |||
|---|---|---|---|
| FGF2 | TCB-32 | TCB-541 | TCB-621 |
| 2mg | 1mg | 1mg | |
| 50mg | 25mg | 25mg | |
| 100mg | 50mg | 50mg | |
Order TCB-32 Order TCB-541 Order TCB-621
References
- Feofanov et al., 2025. Discovery and optimization of a guanylhydrazone-based small molecule to replace bFGF for cell culture applications, Biochem Biophys Rep. 2025 Jul 21;43:102167. PMID: 40734998