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Biological Data
| Biological description | Selective TRPML3 channel activator (EC50 = 1.13 µM). Also Increases intracellular Ca2+ concentrations. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) or ethanol (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 3a,4,5,6,7,7a-Hexahydro-3-(2,4,6-trimethylphenyl)-4,7-methano-1,2-benzisoxazole |
| Chemical structure | ![SN 2 [823218-99-1] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "SN 2 [823218-99-1]") |
| Molecular Formula | C17H21NO |
| PubChem identifier | 11834987 |
| SMILES | CC1=CC(C)=CC(C)=C1C2=NOC3C2C4CCC3C4 |
| InChiKey | WKLZNTYMDOPBSE-UHFFFAOYSA-N |
References for SN 2
References are publications that support the biological activity of the product
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Genetic inactivation of Trpml3 does not lead to hearing and vestibular impairment in mice.
Jörs S et al (2010) PLoS One 5(12) : e14317. -
Small molecule activators of TRPML3.
Grimm C et al (2010) Chem Biol 17(2) : 135-48.
Selective TRPML3 channel activator
![SN 2 [823218-99-1] Chemical Structure](https://media-m2stage.hellobio.com/media/catalog/product//h/b/hb1172.png "SN 2 [823218-99-1]")
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