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Biological Data
| Biological description | Potent SUR1 / Kir6.2 channel blocker (KD = 0.42 nM). Also binds to sulphonylurea receptor 1 (SUR1) alone (KD = 59 nM). Displays antidiabetic properties. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) or ethanol (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 2-Ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benz oic acid |
| Chemical structure | ![Repaglinide [135062-02-1] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Repaglinide [135062-02-1]") |
| Molecular Formula | C27H36N2O4 |
| SMILES | O=C(CC3=CC(OCC)=C(C(O)=O)C=C3)N[C@@H](CC(C)C)C1=CC=CC=C1N2CCCCC2 |
| InChiKey | FAEKWTJYAYMJKF-QHCPKHFHSA-N |
References for Repaglinide
References are publications that support the biological activity of the product
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Novel anti-inflammatory effects of repaglinide in rodent models of inflammation.
Tung D et al (2011) Pharmacology 88(5-6) : 295-301. -
Kir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels.
Hansen AM et al (2005) Br J Pharmacol 144(4) : 551-7. -
Antioxidative and anti-inflammatory effects of repaglinide in plasma of diabetic animals.
Gumieniczek A et al (2005) Pharmacol Res 52(2) : 162-6.
Potent SUR1 / Kir6.2 channel blocker
![Repaglinide [135062-02-1] Chemical Structure](https://m2stage.hellobio.com/media/catalog/product//h/b/hb1106.png "Repaglinide [135062-02-1]")
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