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Biological Data
| Biological description | Caspase-3 activator. Inhibits ProT and stimulates apoptosome formation. Promotes Apaf-1 oligomerization. Shows apoptotic actions. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in HCl (50mM, 1eq. HCl) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | α-(Trichloromethyl)-4-pyridineethanol |
| Molecular Formula | C8H8Cl3NO |
| PubChem identifier | 224859 |
| SMILES | OC(CC1=CC=NC=C1)C(Cl)(Cl)Cl |
| InChiKey | NGTDJJKTGRNNAU-UHFFFAOYSA-N |
References for PETCM
References are publications that support the biological activity of the product
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Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway.
Jiang X et al (2003) Science 299(5604) : 223-6. -
Direct activation of the apoptosis machinery as a mechanism to target cancer cells.
Nguyen JT et al (2003) Proc Natl Acad Sci U S A 100(13) : 7533-8.
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