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Biological Data
| Biological description | Potent CDK1/cyclin B (IC50 = 9. 5 nM) and CDK2/cyclin A3 (IC50 = 5. 4 nM) inhibitor. 1'000-fold more potent than NU2058. Selective for CDK1 and CDK2 compared to CDK4/D1 (IC50 = 1. 6 µM), DYRK1A (IC50 = 0. 9 µM), PDK1 (IC50 = 0. 8 µM) and ROCK-II (IC50 = 0. 6 µM). Inhibits cell growth. |
Solubility & Handling
| Storage instructions | +4°C |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical structure | |
| InChiKey | OWXORKPNCHJYOF-UHFFFAOYSA-N |
| Appearance | White to off-white solid |
Potent CDK1 and CDK2 inhibitor