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Biological Data
| Biological description | GLYT2 and GLYT2(EL2) inhibitor (IC30 values are 5.9 and 6.0 µM). Displays little or no activity at GLYT1 (IC30 = >30 µM). Inhibits pain. |
Solubility & Handling
| Storage instructions | -20°C (desiccate) |
| Solubility overview | Soluble in DMSO (50mM) or ethanol (50mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 2-(Icosa-5,8,11,14-tetraenoylamino)propanoic acid |
| Chemical structure | ![N-Arachidonyl-L-alanine [401941-73-9] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "N-Arachidonyl-L-alanine [401941-73-9]") |
| Molecular Formula | C23H37NO3 |
| PubChem identifier | 53394356 |
| SMILES | C[C@@H](NC(=O)CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)C(=O)O |
References for N-Arachidonyl-L-alanine
References are publications that support the biological activity of the product
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Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport.
Edington AR et al (2009) J Biol Chem 284(52) : 36424-30. -
Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain.
Huang SM et al (2001) J Biol Chem 276(46) : 42639-44.
GLYT2 / GLYT2(EL2) inhibitor
![N-Arachidonyl-L-alanine [401941-73-9] Chemical Structure](https://media-m2stage.hellobio.com/media/catalog/product//h/b/hb0440.png "N-Arachidonyl-L-alanine [401941-73-9]")
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