Mefloquine hydrochloride
(HB9555)
Certificate of Analysis
Product overview
| Name | Mefloquine hydrochloride |
| Purity | >98% |
| Description | Cx36 and Cx50 gap channel blocker. Antimalarial, antischistosomal and antiviral. |
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Biological Data
| Biological description | Cx36 and Cx50 gap channel blocker (IC50 values are 0.3 and 1.1 µM, respectively). Other gap junctions (e.g. Cx43, Cx32, and Cx26) are only affected at concentrations 10-100 fold higher. In neocortical slices, mefloquine blocks gap junctional coupling between interneurons with minimal nonspecific actions. Also shows antimalarial action. Inhibits the 80S ribosome of Plasmodium falciparum to block protein synthesis. Additionally shows antischistosomal and antiviral actions and has recently been investigated as part of COVID-19 compound repurposing. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (50 mM), and in ethanol (100 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Purity | >98% |
| Chemical name | (S)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2R)-piperidin-2-yl]methanol;hydrochloride |
| Molecular Weight | 414.77 |
| Chemical structure | ![Mefloquine hydrochloride [51773-92-3] Chemical Structure](https://m2stage.hellobio.com/media/catalog/product//h/b/hb9555_1.png "Mefloquine hydrochloride [51773-92-3]") |
| Molecular Formula | C17H16F6N2O · HCl |
| CAS Number | 51773-92-3 |
| PubChem identifier | 65329 |
| SMILES | C1CCNC(C1)C(C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F)O.Cl |
| InChi | InChI=1S/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/m1./s1 |
| InChiKey | WESWYMRNZNDGBX-YLCXCWDSSA-N |
| MDL number | MFCD00797519 |
References for Mefloquine hydrochloride
References are publications that support the biological activity of the product
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Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Jeon S et al (2020) Antimicrob Agents Chemother 64 : (7) -
Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis
Wong W et al (2017) Nat Microbiol 2 : 17031 -
Potent block of Cx36 and Cx50 gap junction channels by mefloquine
Cruikshank SJ et al (2004) Proc Natl Acad Sci U S A 101(33) : 12364-9
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