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Biological Data
| Biological description | Protein kinase C (PKC) inhibitor. D-erythro-sphingosine analog. |
Solubility & Handling
| Solubility overview | Soluble in ethanol |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (2S,3S,4E)-2-aminooctadec-4-ene-1,3-diol |
| Chemical structure | ![L-threo-Sphingosine C-18 [25695-95-8] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "L-threo-Sphingosine C-18 [25695-95-8]") |
| Molecular Formula | C18H37NO2 |
References for L-threo-Sphingosine C-18
References are publications that support the biological activity of the product
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Sphingolipid biosynthesis in cultured neurons. Down-regulation of serine palmitoyltransferase by sphingoid bases.
Mandon EC et al (1991) Eur J Biochem 198(3) : 667-74. -
Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds.
Merrill AH Jr et al (1989) Biochemistry 28(8) : 3138-45.
![L-threo-Sphingosine C-18 [25695-95-8] Chemical Structure](https://media-m2stage.hellobio.com/media/catalog/product//h/b/hb0388.png "L-threo-Sphingosine C-18 [25695-95-8]")
Understanding purity and quality - a guide for life scientists