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Biological Data
| Biological description | Jumonji histone demethylase inhibitor. Inhibits JARID1A, JMJD2E/2B/2A/D3/2C (IC50 values are 230, 340, 435, 445, 855 and 1100 nM respectively). Shows little activity at PHD2 (IC50 = > 6 µM) and TET1. Shows anti-cancer actions. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine |
| Chemical structure | ![JIB 04 [199596-05-9] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "JIB 04 [199596-05-9]") |
| Molecular Formula | C17H13ClN4 |
| PubChem identifier | 6519698 |
| SMILES | ClC(C=C3)=CN=C3N/N=C(C2=CC=CC=C2)/C1=CC=CC=N1 |
| InChiKey | YHHFKWKMXWRVTJ-OQKWZONESA-N |
References for JIB 04
References are publications that support the biological activity of the product
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A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth.
Wang L et al (2013) Nat Commun 4 : 2035
Jumonji histone demethylase inhibitor
![JIB 04 [199596-05-9] Chemical Structure](https://media-m2stage.hellobio.com/media/catalog/product//h/b/hb1410.png "JIB 04 [199596-05-9]")
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