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Biological Data
| Biological description | Antibiotic. RNA and DNA synthesis inhibitor. Inhibits topoisomerase I and II and intercalates into DNA to induce DNA damage.
Shows potent anticancer activity.
Recently investigated as part of COVID-19 compound repurposing. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in water (50 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyransoyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride |
| Molecular Formula | C27H29NO10.HCl |
| SMILES | C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O.Cl |
| InChiKey | GUGHGUXZJWAIAS-QQYBVWGSSA-N |
References for Daunorubicin hydrochloride
References are publications that support the biological activity of the product
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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
Krogan et al (2020) Nature 7816 : 459-468 -
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
Marchard et al (2010) Chem Biol. 17(5) : 421-33 -
Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review
Londos-Galgiardi (1984) Biochemie 66(5) : 333-52
RNA and DNA synthesis inhibitor. Antibiotic.
Understanding purity and quality - a guide for life scientists
