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AM 404

(HB1174)
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Product overview

Name AM 404
Purity >98%
Description Selective, competitive carrier-mediated anandamide transport inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4)
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AM 404 product vial image | Hello Bio
AM 404 product vial image | Hello Bio

AM 404 product vial image | Hello Bio

AM 404 product vial image | Hello Bio

Biological Data

Biological description Selective and competitive carrier-mediated anandamide transport inhibitor (IC50 = 1 µM). Activates vanilloid receptors. Shows vasodilator, neuroprotective and anxiolytic actions mediated by 5-HT1A receptors.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in ethanol (50mM) or DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Molecular Weight 395.58
Chemical structure AM 404 [183718-77-6] Chemical Structure
Molecular Formula C26H37NO2
CAS Number 183718-77-6
PubChem identifier 6604822
SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NC1=CC=C(O)C=C1
InChiKey IJBZOOZRAXHERC-DOFZRALJSA-N

References for AM 404

References are publications that support the biological activity of the product

  • 5-HT1A receptors are involved in the anxiolytic effect of Delta9-tetrahydrocannabinol and AM 404, the anandamide transport inhibitor, in Sprague-Dawley rats.

    Braida D et al (2007) Eur J Pharmacol 555(2-3) : 156-63.
    Read more (PubMedID: 17116299)

  • Delta9-tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid receptors.

    Zani A et al (2007) Br J Pharmacol 152(8) : 1301-11.
    Read more (PubMedID: 17965746)

  • Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology.

    Giuffrida A et al (2001) J Pharmacol Exp Ther 298(1) : 7-14.
    Read more (PubMedID: 11408519)

  • The anandamide transport inhibitor AM404 activates vanilloid receptors.

    Zygmunt PM et al (2000) Eur J Pharmacol 396(1) : 39-42.
    Read more (PubMedID: 10822052)

4 Item(s)

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Order: HB1174
Pack PriceQty
10mg
$66
50mg
$263
Selective, competitive carrier-mediated anandamide transport inhibitor
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