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Biological Data
| Biological description | Competitive NMDA receptor partial agonist (Ki = 0.83 mM). Binds at glycine site. Shows 65-fold higher affinity for GluN3 compared to GluN1 subunit. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in water (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 1-Aminocyclobutane-1-carboxylic acid |
| Chemical structure | ![ACBC [22264-50-2] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "ACBC [22264-50-2]") |
| Molecular Formula | C5H9NO2 |
| InChiKey | FVTVMQPGKVHSEY-UHFFFAOYSA-N |
References for ACBC
References are publications that support the biological activity of the product
-
Pharmacology of NMDA Receptors
Monaghan DT et al (2009) 0 : -
Mechanism of partial agonist action at the NR1 subunit of NMDA receptors.
Inanobe A et al (2005) Neuron 47(1) : 71-84. -
1-Aminocyclobutane-1-carboxylate (ACBC): a specific antagonist of the N-methyl-D-aspartate receptor coupled glycine receptor.
Hood WF et al (1989) Eur J Pharmacol 161(2-3) : 281-2.
Competitive NMDA receptor partial agonist
![ACBC [22264-50-2] Chemical Structure](https://media-m2stage.hellobio.com/media/catalog/product//h/b/hb0100.png "ACBC [22264-50-2]")
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