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(-)-[3R,4S]-Chromanol 293B

(HB1076)
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Product overview

Name (-)-[3R,4S]-Chromanol 293B
Purity >98%
Description Selective delayed rectifier K+ current inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Selective delayed rectifier K+ current (IKs) inhibitor (IC50 = 1.36 µM). Enantiomer of Chromanol 293B; more potent than the (+)-(3S,4R) enantiomer (IC50 = 9.6 µM). Shows an open channel time-dependent block.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in ethanol (100mM, gentle warming) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide
Molecular Weight 324.39
Chemical structure (-)-[3R,4S]-Chromanol 293B [163163-24-4] Chemical Structure
Molecular Formula C15H20N2O4S
CAS Number 163163-24-4
PubChem identifier 121846
SMILES CCS(=O)(=O)N(C)[C@@H]1[C@@H](O)C(C)(C)OC2=C1C=C(C=C2)C#N
InChi InChI=1S/C15H20N2O4S/c1-5-22(19,20)17(4)13-11-8-10(9-16)6-7-12(11)21-15(2,3)14(13)18/h6-8,13-14,18H,5H2,1-4H3/t13-,14+/m0/s1
InChiKey HVSJHHXUORMCGK-UONOGXRCSA-N

References for (-)-[3R,4S]-Chromanol 293B

References are publications that support the biological activity of the product

  • A kinetic study on the stereospecific inhibition of KCNQ1 and I(Ks) by the chromanol 293B.

    Seebohm G et al (2001) Br J Pharmacol 134(8) : 1647-54.
    Read more (PubMedID: 11739240)

  • Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels.

    Yang IC et al (2000) J Pharmacol Exp Ther 294(3) : 955-62.
    Read more (PubMedID: 10945846)

  • Molecular impact of MinK on the enantiospecific block of I(Ks) by chromanols.

    Lerche C et al (2000) Br J Pharmacol 131(8) : 1503-6.
    Read more (PubMedID: 11139424)

3 Item(s)

Grouped product items
Order: HB1076
Pack PriceQty
1mg
$35
5mg
$126
10mg
$184
50mg
$660
Selective delayed rectifier K+ current inhibitor
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